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5 HTP --- Side Effects:

5-HTPA Side Effects

What are the Side Effects to 5-HTP ?

5-HTP was released in 1994, and long term effects, or the effects of long term use, are still unknown. It is thought, that in safe doses, that there will be no, or little long term side effects, as all the capsules do is restore a depleted natural chemical in the body, but the effects of extreme doses are unknown.
What is known are the short term possible side effects:
(These have been shown in higher dosages, typically over 100mgs)
nausea, vomiting, stomach cramps, nightmares, and decreased sex drive, constipation, gas, drowsiness. Other side effects reported in large dosages (100MG+) include nightmares.
It is however, worth noting that side effects are reported to be fewer, and more unlikely then when taking a traditional antidepressant.

Dosages of 5-HTP greater than 100MG per day should only be taken under the guidance of your GP. -- There is a very serious reason for this, please read below:

Serotonin Syndrome:

This dangerous and a potentially fatal condition usually occurs when your body contains too much Serotonin, as a result from serotonergic enhancing drugs, but can also be a result of taking too many drugs that increase your Serotonin at the same time, such as being on a Selective Serotonin Reuptake Inhibitor (SSRI e.g., Prozac); Tricyclic medications, at the same time.
Signs of Serotonin Syndrome include: euphoria, drowsiness, sustained rapid eye movement, overreaction of the reflexes, rapid muscle contraction and relaxation in the ankle causing abnormal movements of the foot, clumsiness, restlessness, feeling drunk and dizzy, muscle contraction and relaxation in the jaw, sweating, intoxication, muscle twitching, rigidity, high body temperature.

When NOT to take 5-HTP Capsules:

Do NOT take 5-HTP capsules if you suffer from any of the following:

Cardiovascular Diseases (post-stroke, high blood pressure, post-heart attack); Extremely Elderly Persons; those with Parkinsons; Disease, Cancer or Autoimmune Diseases (Scleroderma, Arthritis, Rheumatoid, Lupus, Multiple Sclerosis); Lung Diseases; Chronic Alcoholism; Liver diseases (hepatitis or cirrhosis); parasitic infection; AIDS; Anorexia Nervosa; Low protein Diets; Allergies (severe); Myalgia (persistent pain and weakness of the muscles); Peripheral Neuropathy (pain weakness of the muscles); Rash or Flushing; Edema; Nausea; Diarrhea; Sickle cell anemia; hemophilia; Pregnancy.

Do NOT take 5-HTP capsules if you are taking any of the following:

Anti-depressant drugs; Monoamine oxidase inhibitors; Selective Serotonin Reuptake Inhibitors (SSRI's e.g., Prozac); Tricyclic medications; Weight Loss medications (i.e., dextenfluramine); Anti-parkinson medications (e.g., L-dopa); Barbiturates and other tranquilizing drugs; Antihistamines and cold medications; Alcoholic beverages; Intravenous (illegal I.V.) drugs; Cancer chemotherapy or antibiotic medications.

IF you do decide to take 5-HTP capsules, always be alert for unwanted side effects. If you start feeling physically or mentally uncomfortable, stop the taking the capsules, and symptoms should disappear, if in doubt consult your GP.



More infomation about 5-HTP in genral can be read on this page

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